Table 2.

Worldwide distribution of the most common TMPT alleles in healthy subjects.

Region	Country	Total alleles	*2 (%)	*3A (%)	*3B (%)	*3C (%)	Deficiency alleles (%)	Reference
Central and South America	Guatemala	324	0.85	5.6	0	0.56	7 .1	Current study
	Colombia	280	0.4	3.6	0	0	4.0	[7]
	Argentina	294	0.7	3.1	0	0.2	4.0	[8]
	Brazil	408	2.1	1.5	0.2	1	4.8	[9]
	Bolivia	230	0	6.5	0	0	6.5	[10]
	Chile	420	0.24	2.9	0	0.71	3.8	[11]
North- America	Mexico	216 300 720	0.9 0 0.28	3.24 3.0 5.7	2.3 0.3 0.28	1.4 2.0 0.56	7.8 5.3 6.8	[12] [13] [14]
	USA  Caucasian   African-  descendent	564 496	0.17 0.4	3.2 0.8	0 0	0.17 2.4	3.5 3.6	[15]
Europe	British	398	0.5	4.5	0	0.3	5.1	[16]
	Portugal	274	1.1	2.4	0	0.7	4.2	[17]
	France	608	0.7	3.0	0	0.4	4.1	[18]
	Sweden	1600	0.06	3.8	0.13	0.44	4.0	[19]
	Germany	2428	0.2	4.4	0	0.4	4.8	[20]
	Slovenia	388	0	4.1	0.3	0.5	4.9	[21]
	Sardinia	518	1.74	0.58	0.39	0.77	6.9	[22]
	Spain  Spaniards   Basque    Gypsy	276 102 198	- - -	3.3 2.9 2.0	1.4 0.98 1.5	1.4 0 0	6.1 3.9 3.5	[23]
	Czech	1392	0.1	4.3	0.1	0.4	4.9	[24]
	Russia	1990	0.1	2.3	0	0.4	2.0	[25]
	Italia	1886	-	2.2	0.26	0.26	2.7	[26]
	Poland	788	0.38	3.15	0	0.13	3.7	[27]
Asia	Japan*	384 302	0 0	0 0	0 0	0.8 0.3	0.8* 0.3*	[28] [29]
	China	1404	0	0.02	0	0.9	0.92*	[30]
	Taiwan  Aborigines	354 818	0	0	0	1.2 0.12	1.2* 0.12	[31]
	India	400	0	0.5	0	0.8	1.3*	[32]
	Tibet	100	0	0	0	1	1.0*	[10]
Middle- East	Turkish	212	0.9	0.9	0	0.9	2.7*	[33]
	Iran	1664 1000	2.16 0.1	1.68 0	1.62 0	0.54 2.5	6.0 2.6*	[34] [35]
	Jordania	338	0	1.2	0	0.6	0.89*	[36]
	Izrael	388	0	1.8	0	1.1	1.8*	[37]
Africa	Ghana	434	0	0	0	7.6	7.4	[16]
	Kenya	202	0	0	0	5.4	5.4	[38]
	Egypt	400	0	0.3	0	1.3	1.6*	[39]
	Mozanbique	472	0	0.2	0	3.8	4.0	[17]

^*p< 0.05 statistical differences in the distribution of the mutant alleles among Guatemala and these populations