Table 6.
Associations between genus-beta HPV seropositivity and SCC in the absence or presence of concordant genus-beta HPV DNA in plucked eyebrow hairs (A) and associations between the presence of genus-beta HPV DNA in plucked eyebrow hairs and SCC in the absence or presence of antibodies to the same or discordant HPV types (B).
| Genus-beta HPV seropositivity and viral DNA status of eyebrow (EB) hairs | Controls (n = 290) n (%) |
SCC (n = 168) | ||
|---|---|---|---|---|
| n (%) | OR | (95% CI)1 | ||
| A2 | ||||
| Seronegative regardless of EB DNA | 117 (40.3) | 46 (27.4) | 1.00 | (reference) |
| Seropositive without concordant EB DNA | 110 (37.9) | 64 (38.1) | 1.73 | (0.97–3.10) |
| Seropositive with concordant EB DNA | 63 (21.7) | 58 (34.5) | 1.42 | (0.75–2.68) |
| B | ||||
| Seronegative/EB DNA negative | 36 (12.4) | 5 (3.0) | 1.00 | (reference) |
| Seropositive/EB DNA negative | 41 (14.1) | 17 (10.1) | 1.92 | (0.56–6.61) |
| Seronegative/EB DNA positive | 81 (27.9) | 41 (24.4) | 1.90 | (0.62–5.77) |
| Seropositive/EB DNA positive for discordant types | 69 (23.8) | 47 (28.0) | 3.36 | (1.12–10.07) |
| Seropositive/ EB DNA positive for concordant types | 63 (21.7) | 58 (34.5) | 2.37 | (0.78–7.19) |
1
Odds ratios (OR) and 95% confidence intervals (CI) adjusted for age, sex, education, hair color, occupational sunlight exposure, tanning ability and ever smoking at least 100 cigarettes in lifetime.
2
Analysis modeled after Proby et al. Am J Transplant 2011.