Table 1.
Relationship between miR-101 expression levels and clinicopathological parameters for the present LSCC cohort
| Clinicopathological parameters | N (No. of patients) | Level of miR-101 expression (T/N ratio)a | P value |
|---|---|---|---|
| Patient gender | 0.776 | ||
| Male | 56 | 0.208 ± 0.056 | |
| Female | 24 | 0.212 ± 0.059 | |
| T classification | 0.015 | ||
| T1–2 | 40 | 0.225 ± 0.054 | |
| T3–4 | 40 | 0.194 ± 0.055 | |
| Lymph node metastasis | 0.044 | ||
| Negative | 45 | 0.221 ± 0.051 | |
| Positive | 35 | 0.195 ± 0.06 | |
| Differentiation | 0.096 | ||
| Well | 54 | 0.202 ± 0.053 | |
| Moderately/poorly | 26 | 0.225 ± 0.061 | |
| Patient age | 0.051 | ||
| ≥60 years | 48 | 0.212 ± 0.050 | |
| <60 years | 32 | 0.206 ± 0.065 | |
| Clinical stage | 0.004 | ||
| I–II | 38 | 0.228 ± 0.054 | |
| III–IV | 42 | 0.192 ± 0.053 | |
| Tobacco exposure | 0.638 | ||
| Smoker | 60 | 0.208 ± 0.060 | |
| Nonsmoker | 20 | 0.215 ± 0.045 | |
| miR-101 levels | <0.01 | ||
| Low | 40 | 0.166 ± 0.030 | |
| High | 40 | 0.253 ± 0.039 |
aTumour/normal (T/N) ratio: fold change in miR-101 expression in LSCC tissue to the corresponding adjacent normal tissue. MiR-101 expression was measured by real-time PCR and was normalized to an external control (human U6 gene). Values were quantified using the 2−ΔΔCt method. Values are presented as the mean ± SD.