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. 2015 Aug 19;3:50. doi: 10.1186/s40478-015-0229-8

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© Miermeister et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Diagnostic criteria for atypical pituitary adenomas. An example of an atypical pituitary adenoma (ACTH-cell adenoma) with several mitotic figures (Arrows in a) in one HPF (HE staining, magnification 400x), infiltration of surrounding meninges (Arrows in b, HE staining, magnification 100x), Ki67 index >4 % (c, magnification 400x) and strong nuclear p53 expression in >3 % of cells (d, magnification 400x; Arrows: negative endothelial cells indicating antibody specificity)