Table 4.
Multivariate analysis of overall survival
| Variables | Training cohort |
Validation cohort |
|||||
|---|---|---|---|---|---|---|---|
| HR | (95% CI) | P | HR | (95% CI) | P | ||
| Age | >65 vs. ≤65 | 1.29 | (0.87 – 1.91) | 0.20 | 2.51 | (1.36 – 4.64) | 0.003 |
| Sex | males vs. females | 1.24 | (0.89 – 1.71) | 0.20 | 1.43 | (0.88 – 2.31) | 0.15 |
| Smoking pack-year | >90 vs. ≤90 | 1.46 | (1.00 – 2.14) | 0.048 | 0.84 | (0.45 – 1.55) | 0.57 |
| Surgery | limited resection vs. lobectomy | 1.42 | (0.94 – 2.15) | 0.096 | 1.15 | (0.58 – 2.26) | 0.69 |
| Pathological stage | Stage II vs. Stage I | 1.43 | (0.98 – 2.10) | 0.064 | 1.19 | (0.67 – 2.10) | 0.56 |
| Stage III vs. Stage I | 2.15 | (1.35 – 3.43) | 0.001 | 2.20 | (1.04 – 4.66) | 0.040 | |
| Lymphovascular invasion | present vs. absent | 1.06 | (0.75 – 1.50) | 0.73 | 2.14 | (1.21 – 3.77) | 0.009 |
| CD10/CD20 risk index | high-risk vs. low-risk | 1.61 | (1.15 – 2.27) | 0.006 | 1.75 | (1.02 – 3.01) | 0.043 |
Significant P-values are shown in bold.
HR, hazard ratio; CI, confidence interval