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. 2015 Aug 19;10(8):e0136175. doi: 10.1371/journal.pone.0136175

Fig 7. Effect of SDF-1 Neutralization on laser-induced CNV in LPS-treated mice.

Fig 7

Male adult Brown Norway rats received a single intravitreal injection of 10 μl LPS at 10 ng/ml (equivalent to an intravitreal centration of approximately 2 ng/ml) in eyes at one day before laser photocoagulation. The control rats received the same volume of vehicle (PBS). For some of LPS-treated rats, 1 μg anti-SDF-1 antibody in a 10-μl volume was injected immediately after laser photocoagulation. (A) Representative fluorescein angiography at 7 days after laser photocoagulation. (B) Representative images of isolectin B4 stain of RPE-choroid-sclera whole mount that performed 7 days after laser. (C) Quantitative measurement of CNV area. Data shown are mean ± SD of triplicate samples and are representative of four independent experiments. Statistical significance determined using one-way ANOVA with *P < 0.05, **P < 0.01.