Fig. 2.

Combination of SC4 and Zosyn show enhanced protection against bacteria. SC4 and Zosyn were used in mouse bacteria model to assess in vivo efficacy against P.a.. The compounds were administered for 3 days by osmotic mini-pumps starting one day prior to i.p. injection of P.a. into C57/BL6 mice (n=20–34/group). Each mouse received a lethal dose of P.a. (300 µl of Klett 70). Survival of the mice were monitored for 14 days, however since no change in survival was noted after 120 hours, up to day 5 is plotted. *p < 0.03 (treatment group vs. control).