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. Author manuscript; available in PMC: 2016 Apr 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Feb 15;284(2):204–216. doi: 10.1016/j.taap.2015.02.008

Figure 6. Delayed post-treatment with the GluK1R antagonists LY293558 or UBP302 arrests soman-induced seizures in P21 rats.

Figure 6

Rats were exposed to 1.2 X LD50 soman (74.4 μg/kg) and treated with ATS (0.5 mg/kg) and HI-6 (125 mg/kg) at 1 min post-exposure. At 1 hr post-exposure, rats received LY293558 (20 mg/kg; n = 15), or UBP302 (250 mg/kg; n = 18), or the drug vehicle (n = 16). ***p < 0.001 for the difference in seizure score of the LY293558-treated and UBP302-treated groups compared to the vehicle-treated group (MANOVA, Bonferroni post-hoc test).