TABLE I.
Level of Information Provided Regarding Phenotypic Characteristics of Individuals With Classic Dup7 Reported in Prior Literature
| Level of Information Provideda |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| < 4 Years (N = 10b) | 4–17 Years (N = 35) | Adult (N = 13) | |||||||
|
|
|||||||||
| Characteristic | Not Addressed |
Class. or Description Only |
Standard. Assessmentc |
Not Addressed |
Class. or Description Only |
Standard. Assessmentc |
Not Addressed |
Class. or Description Only |
Standard. Assessmentc |
| Intellectual ability/disability | 30.0 | 60.0 | 10.0 | 5.7 | 62.9 | 31.4 | 53.8 | 46.2 | 0.0 |
| Language ability/disability | 10.0 | 90.0 | 0.0 | 20.0 | 62.9 | 17.1 | 53.8 | 46.2 | 0.0 |
| Adaptive behavior | 100.0 | 0.0 | 0.0 | 80.0 | 8.6 | 11.4 | 53.8 | 46.2 | 0.0 |
| Anxiety (present or absent) | 80.0 | 20.0 | 0.0 | 65.7 | 20.0 | 14.3 | 69.2 | 30.8 | 0.0 |
| Attention problems (present or absent) |
90.0 | 0.0 | 10.0 | 48.6 | 28.6 | 22.9 | 92.3 | 7.7 | 0.0 |
| Aggression/oppositional behavior (present or absent) |
90.0 | 0.0 | 10.0 | 62.9 | 20.0 | 17.1 | 84.6 | 15.4 | 0.0 |
| Autism spectrum disorder (present, absent, autistic features) |
50.0 | 40.0 | 10.0 | 42.9 | 25.7 | 31.4 | 69.2 | 30.8 | 0.0 |
Note: Class. = Classification, Standard. = Standardized
Cell values are percentages; slight deviations of the sum of percentages for a particular age group in a single row from 100 are due to rounding.
One additional participant (aged 6 mos.) was excluded because s/he was too young to be evaluated for most of these characteristics. S/he was described as having “global developmental delay.”
For intellectual ability/disability, language ability/disability, and adaptive behavior, a child was included in this category if at least one standard score from an appropriate assessment was provided. For anxiety, attention problems, and aggression/oppositional behavior, a child was included in this category if at least one T-score from an appropriate assessment (in all cases, a standardized questionnaire completed by a parent or a teacher) was provided or the authors indicated that the child’s classification as demonstrating/not demonstrating this characteristic was based on his/her T-score from such an assessment. For autism spectrum disorder, a child was included in this category if s/he completed the Autism Diagnostic Observation Schedule [Lord et al., 1999] or Autism Diagnostic Observation Schedule-2 [Lord et al., 2012] and/or a parent completed the Autism Diagnostic Interview – Revised [Lord et al., 1994] (11 of the 12 children) or if a parent or teacher completed a standardized questionnaire for autistic symptoms (1 child).