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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Curr Top Med Chem. 2015;15(20):2032–2042. doi: 10.2174/1568026615666150519102459

Figure 3. Schematic representation of the Fragment-Inspired HTS by NMR approach.

Figure 3

a) Fragment hits are identified by screening methods and/or by de-fragmentation of known inhibitors or of natural substrates (such as an ATP mimetic, a metal chelating group, a phospho-Tyrosine mimetic, etc.). b) SAR studies, including possibly structural information, are performed with a selected fragment hit to provide suggestions on a suitable position to place a linker to be used for synthesis of the POS library. c) The optimized fragment is introduced into the POS combinatorial library to be tested using the HTS by NMR strategy.