Table 3.
Lipids at baseline and 12-months.
| Variables | Mono-Therapy (n=48) | Triple-Therapy (n=47) | P-value |
|---|---|---|---|
| Baseline Lipids | |||
| Total cholesterol (mg/dl) | 173.5 (139, 198) | 162.0 (134, 202) | 0.50 |
| HDL cholesterol (mg/dl) | 41.5 (34, 48) | 39.0 (32, 46) | 0.54 |
| LDL cholesterol (mg/dl)⟂ | 96.0 (73, 113) | 88.0 (69, 120) | 0.85 |
| Non-HDL cholesterol (mg/dl) | 125.5 (98, 160) | 120.0 (95, 149) | 0.63 |
| Triglycerides (mg/dl) | 146.5 (99, 212) | 134 (95, 177) | 0.58 |
| hs-CRP (mg/L) | 2.97 (1.77, 6.17) | 3.31 (1.79, 8.08) | 0.59 |
| Lipid Data at 12-Months (change from baseline) | |||
| Variable | Mono-Therapy (n=36) | Triple-Therapy (n=31) | P-value* |
| Total cholesterol (mg/dl) | −7.50 (−30.50, 8.00) | −30.00 (−63.00, −1.00) | 0.040 |
| HDL cholesterol (mg/dl) | −0.50 (−4.00, 4.60) | 4.00 (−5.00, 9.00) | 0.13 |
| LDL cholesterol (mg/dl)‡ | −8.00 (−20.00, 4.00) | −28.00 (−48.00, −4.10) | 0.028 |
| Non-HDL cholesterol (mg/dl) | −5.50 (−30.00, 11.00) | −29.00 (−67.00, −12.00) | 0.012 |
| Triglycerides (mg/dl) | −1.50 (−68.50, 51.50) | −33.0 (−71.00, 10.00) | 0.12 |
| hs-CRP (mg/L)† | 0.26 (−1.35, 1.66) | −0.24 (−1.68, 0.51) | 0.17 |
All values are medians and interquartile range (IQR). P-values were calculated with the Kruskal-Wallis rank test. hs-CRP= high sensitive c-reactive protein.
P-values indicate group differences with respect to change from baseline. To convert from mg/dl to mmol/l, multiply by 0.026.To convert HDL-C or LDL-C from mg/dl to mmol/L, multiply by 0.0259. To convert triglycerides from mg/dl to mmol/l, multiply by 0.0113.
LDL-C: N=45 for each group. LDL-C was not calculated for 5 patients (n=3 in mono-therapy group, n=2 in triple-therapy group) with TG≥400 mg/dl. Estimation of LDL-C using the Friedewald formula is inaccurate when TG≥400 mg/dl.39
LDL-C: n=32 in mono-therapy group and n=30 in triple-therapy group.
CRP: n=29 in triple-therapy group.