Table 2.
Diseases in Which NOX2 Is Implicated
| Disease | Type of evidence for NOX2 role | References |
|---|---|---|
| Hypertension | NOX2 siRNA in mice | (220) |
| Apocynin in mice | (303) | |
| Acute lung inflammation | NOX2 KO mice | (216, 217, 315, 316, 340) |
| p47phox KO mice | (114, 340) | |
| Chronic obstructive pulmonary disease | P47phox KO mice | (150) |
| Apocynin effects on H2O2 in patients | (283) | |
| Asthma | Steroids lower NOX2 in patients | (203) |
| Apocynin effects on H2O2 in patients | (284) | |
| Ebselen effects in guinea pigs | (338) | |
| Cystic fibrosis | Neutrophil infiltration seen in patients | (95) |
| Pulmonary hypertension | NOX2 KO mice | (198) |
| NOX2 activation and apocynin effects in lamb model | (302) | |
| Ischemia-reperfusion injury in lung | p47phox KO mice | (333) |
| Apocynin effects in mice, rats, and sheep | (43, 215, 333) | |
| Ischemic stroke | NOX2 KO mice | (116, 167, 297) |
| Apocynin effects in mice | (116, 295) | |
| VAS3870 effects in mice | (140) | |
| Traumatic brain injury | NOX2 KO mice | (64) |
| Apocynin effects in mice | (45, 279, 339) | |
| gp91(NOX2)ds-tat peptide in mice | (339) | |
| Alzheimer's disease | Aβ peptides activate ROS and cytokine production in vitro | (23) |
| gp91 (NOX2) activation in human AD brain | (10, 270) | |
| NOX2 KO mice | (209) | |
| gp91(NOX2)ds-tat inhibitor peptide in mice | (210) | |
| Parkinson's disease | NOX2 KO mice | (331) |
| NOX2 increased in human PD brain | (331) | |
| Amyotrophic lateral sclerosis | NOX2 increased in ALS patients | (330) |
| NOX2 KO mice | (175, 330) | |
| Apocynin effects in mice | (94) | |
| Schizophrenia | NOX2 increased in neurons in mouse models | (19, 280) |
| Apocynin effects in rodents | (19, 258, 280) | |
| NOX2 KO mouse | (280) | |
| p47phox mutated rat | (258) | |
| Muscle disorders | NOX2 activated by stretch in rodent in vitro models | (231) |
| NOX2 in muscle activated in mdx mice | (135) | |
| DPI inhibitor effects in vitro | (231) | |
| gp91(NOX2)ds-tat peptide inhibitor in vitro | (135, 231) | |
| NOX2 KO mice | (231) |
AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; DPI, diphenylene iodonium H2O2, hydrogen peroxide; PD, Parkinson's disease.