Table 1.
Baseline characteristics of patients with and without hypogammaglobulinemia at CLL diagnosis
| Characteristic | Hypogammaglobulinemia at diagnosis, (%) or [range] |
Normal IgG at diagnosis (%) or [range] |
p-value | |
|---|---|---|---|---|
| Number of patients | 382 | 1103 | ||
| Median serum IgG level (mg/dL) | 624 [111–755] | 1040 [757–4000] | ||
| Median age, years | 62 [37–94] | 64 [27–94] | 0.11 | |
| Male | 268 (70) | 716 (65) | 0.06 | |
| Rai Stage | Low risk (0) | 187 (49) | 620 (56) | 0.001 |
| Intermediate risk (I–II) | 160 (42) | 433 (39) | ||
| High risk (III–IV) | 32 (8) | 45 (4) | ||
| IGHV mutation* | Mutated | 140 (54) | 391 (58) | 0.21 |
| Unmutated | 121 (46) | 281 (42) | ||
| ZAP-70* | Negative (<20%) | 185 (61) | 505 (67) | 0.08 |
| Positive (≥20%) | 119 (39) | 254 (33) | ||
| CD38* | Negative (<30%) | 246 (70) | 703 (72) | 0.37 |
| Positive (≥30%) | 106 (30) | 268 (28) | ||
| CD49d* | Negative (<30%) | 135 (57) | 440 (75) | <0.0001 |
| Positive (≥30%) | 103 (43) | 150 (25) | ||
| FISH* | deletion13q | 124 (42) | 328 (40) | 0.32 |
| normal | 66 (22) | 232 (28) | ||
| +12 | 61 (21) | 140 (17) | ||
| deletion11q | 30 (10) | 69 (8) | ||
| deletion17p | 11 (4) | 39 (5) | ||
*
Not available for all patients