Table 2.
Baseline characteristics of CLL patients with hypogammaglobulinemia that is subdivided by three terciles
| Characteristic | Lower Tercile IgG <585 mg/dL (%) or [range] |
Middle Tercile IgG: 585–687 mg/dL (%) or [range] |
Upper Tercile IgG: 688–756 mg/dL (%) or [range] |
p- value |
|
|---|---|---|---|---|---|
| Number of patients | 127 | 127 | 128 | ||
| Median serum IgG, mg/dL | 500 [111–584] | 623 [585–687] | 711 [688–755] | ||
| Median age, years | 62 [39–90] | 62 [41–92] | 62 [37–94] | 0.8 | |
| Male | 96 (76) | 87 (68) | 85 (66) | 0.24 | |
| Rai Stage | Low risk (0) | 52 (42) | 63 (50) | 72 (57) | 0.01 |
| Intermediate risk (I–II) | 54 (43) | 56 (44) | 50 (39) | ||
| High risk (III–IV) | 19 (15) | 8 (6) | 5 (4) | ||
| IGHV mutation | Mutated | 40 (47) | 52 (58) | 48 (56) | 0.32 |
| Unmutated | 45 (53) | 38 (42) | 38 (44) | ||
| ZAP-70 | Negative (<20%) | 54 (54) | 59 (60) | 72 (68) | 0.13 |
| Positive (≥20%) | 45 (45) | 40 (40) | 34 (32) | ||
| CD38 | Negative (<30%) | 75 (65) | 79 (67) | 92 (78) | 0.06 |
| Positive (≥30%) | 41 (35) | 39 (33) | 26 (22) | ||
| CD49d | Negative (<30%) | 34 (44) | 47 (57) | 54 (68) | 0.01 |
| Positive (≥30%) | 43 (56) | 35 (43) | 25 (32) | ||
| FISH | deletion13q | 35 (35) | 46 (46) | 43 (44) | 0.06 |
| normal | 19 (19) | 19 (19) | 28 (29) | ||
| +12 | 29 (29) | 23 (23) | 9 (9) | ||
| deletion11q | 12 (12) | 7 (7) | 11 (11) | ||
| deletion17p | 4 (4) | 2 (2) | 5 (5) | ||