Table 1.
Top 5 networks observed to be affected in liver tissue based on differentially expressed transcripts or proteins using Ingenuity Pathway Analysis
| Transcriptomics results | |
| Female, Liver, Tissue, 3 mg/k/day | Network function score |
| Carbohydrate Metabolism, Behavior, Genetic Disorder | 21 |
| Cellular Growth and Proliferation, Cell Death, DNA Replication, Recombination, and Repair | 19 |
| Cellular Growth and Proliferation, Cellular Movement, Cancer | 17 |
| Cellular Growth and Proliferation, Hematological System Development and Function, Inflammatory Response | 15 |
| Cell-To-Cell Signaling and Interaction, Hair and Skin Development and Function, Tissue Development | 10 |
| Male, Liver Tissue, 3 mg/kg/day | |
| Antigen Presentation, Cell-To-Cell Signaling and Interaction, Hematological System Development and Function | 23 |
| Lipid Metabolism, Molecular Transport, Small Molecular Biochemistry | 20 |
| Cellular Development, Cell Cycle, DNA Replication, Recombination, and Repair | 15 |
| Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry | 15 |
| Cellular Growth and Proliferation, Small Molecular Biochemistry, Cancer | 15 |
| Female, Liver Tissue, 14 mg,/kg/day | |
| Lipid Metabolism, Small Molecular Biochemistry, Cellular Development | 61 |
| Cell Death, Cellular, Tissue Development | 21 |
| Organismal Injury and Abnormalities, Antigen Presentation, Humoral Immune Response | 19 |
| Cancer, Dermatological Diseases and Conditions, Cellular Development | 18 |
| Cell Death, Organ Morphology, Lipid Metabolism | 15 |
| Male, Liver Tissue, 14 mg/kg/day | |
| Lipid Metabolism, Small Molecular Biochemistry, Cellular Development | 21 |
| Lipid Metabolism, Small Molecular Biochemistry, Cellular Movement | 19 |
| Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism | 18 |
| Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism | 16 |
| Cell-To- Cell Signaling and Interaction, Tissue Development, Cellular Movement | 16 |
| Female, Liver Tissue, 30 mg/kg/day | |
| Organism Functions, Cell Death, Carbohydrate Metabolisms | 19 |
| Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism | 18 |
| Cellular Growth and Proliferation, Skeletal and Muscular System Development and Function, Cellular Function and Maintenance | 16 |
| Lipid Metabolism, Small Molecular Biochemistry, Vitamin and Mineral Metabolism | 16 |
| Cellular Movement, Nervous System Development and Function, Organ Development | 16 |
| Male, Liver Tissue, 30 mg/kg/day | |
| DNA Replication, Recombination, and Repair, Protein Degradation, Protein Synthesis | 20 |
| Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry | 18 |
| Lipid Metabolism, Molecular Transport, Small Molecular Biochemistry | 17 |
| Cell Cycle, Cellular Development, Cellular Assembly, and Organization | 17 |
| Cell Cycle, Hair and Skin Development and Function, Cellular Development | 15 |
| Proteomics Results | |
| Female, Liver 30 mg/kg/day | Network Functions Score |
| Cell-To-Cell Signaling and Interaction, Tissue Development, Lipid Metabolism | 28 |
| Cell-To-Cell Signaling and Interaction, Tissue Development, Cell Morphology | 18 |
| Amino acid Metabolism, Small Molecular Biochemistry, Cellular Assembly and Organization | 18 |
| Drug Metabolism, Endocrine System Development and Function, Lipid Metabolism | 18 |
| Cell Death, Cellular Growth and Proliferation, Nervous System Development and Function | 17 |
| Male, Liver 30 mg/kg/day | |
| Organismal Injury and Abnormalities, Respiratory Disease, Genetic Disorder | 24 |
| Lipid Metabolism, Molecular Transport, Small Molecular Biochemistry | 22 |
| Cell Morphology, Cellular Development, Nervous System Development and Function | 18 |
| Lipid Metabolism Small, Molecular Biochemistry, Molecular Transport | 15 |
| Gene Expression, Endocrine System Development and Function, Nervous System Development and Function | 2 |