Table 3.

Sample size calculations derived from an ordinal regression and based on 90 % power and alpha 0.05

Trial	Sample size	Common odds ratio	% mRS 0–2 fluoxetine	% mRS 0–2 placebo	Absolute % improvement in mRS 0-2
EFFECTS	1500	1.35	49.5	42.1	7.4
AFFINITY	1600	1.34	49.4	42.2	7.2
FOCUS	3000	1.23	48.4	43.2	5.2
Pooled	4500	1.19	48.0	43.6	4.4
Pooled	6000	1.16	47.7	44.0	3.7