Table 3.
Mean baseline clinical characteristics
| Outcome measure | Treatment | Placebo | |||
|---|---|---|---|---|---|
| Normal range | Median (Min, Max) | Mean (SD) | Median (Min, Max) | Mean (SD) | |
| Thyroid function tests: | |||||
| TSH (mIU/L) | 0.40–3.50 | 0.96 (0.00, 55.77) | 2.98 (8.39)a | 1.34 (0.01, 7.30) | 1.85 (1.76) |
| FT4 (pmol/L) | 9.0–19.0 | 15.00 (7.00, 26.00) | 15.09 (3.22) | 14.20 (3.80, 24.50) | 14.51 (3.91 |
| FT3 (pmol/L) | 2.6–6.0 | 4.06 (2.80, 7.45) | 4.13 (0.80) | 3.80 (3.00, 5.73) | 3.95 (0.64) |
| DASS Scores: | |||||
| Depression | 0–9 | 6.50 (0.00, 29.00) | 9.43 (8.60) | 6.00 (0.00, 41.00) | 7.85 (8.52) |
| Anxiety | 0–7 | 6.00 (0.00, 19.00) | 6.79 (5.13) | 4.00 (0.00, 30.00) | 6.27 (7.73) |
| Stress | 0–14 | 13.00 (3.00, 35.00) | 13.71 (8.28) | 11.00 (2.00, 38.00) | 12.76 (8.53) |
| SF-36v2 Scores: | Normal Mean (SD) | Median (Min, Max) | Mean (SD) | Median (Min, Max) | Mean (SD) |
| Physical functioning | 50 ± 3 (10) | 52.82 (25.46, 57.03) | 48.06 (8.36) | 50.72 (29.68, 57.03) | 48.66 (7.72) |
| Role physical | 50 ± 3 (10) | 49.51 (22.57, 56.85) | 48.85 (8.60) | 51.96 (17.67, 56.85) | 46.32 (11.25) |
| Bodily pain | 50 ± 3 (10) | 46.06 (24.08, 62.12) | 49.97 (9.87) | 46.06 (24.08, 62.12) | 46.53 (9.43) |
| General health | 50 ± 3 (10) | 45.31 (23.38, 57.70) | 43.72 (11.26) | 45.78 (23.78, 62.47) | 45.16 (9.71) |
| Vitality | 50 ± 3 (10) | 39.60 (23.99, 58.33) | 40.15 (8.88) | 41.16 (20.87, 58.33) | 41.68 (10.33) |
| Social functioning | 50 ± 3 (10) | 45.94 (13.22, 56.86) | 42.09 (12.49) | 45.94 (13.22, 56.85) | 41.12 (12.82) |
| Role emotional | 50 ± 3 (10) | 48.10 (20.89, 55.88) | 44.78 (10.71) | 44.22 (20.89, 55.88) | 43.58 (10.96) |
| Mental health | 50 ± 3 (10) | 44.38 (21.85, 61.27) | 43.79 (11.04) | 47.19 (16.22, 58.46) | 43.03 (11.62) |
| Physical component summary | 50 ± 3 (10) | 50.46 (30.08, 61.73) | 48.27 (7.76) | 51.39 (16.70, 59.78) | 48.45 (9.54) |
| Mental component summary | 50 ± 3 (10) | 42.59 (16.70, 60.18) | 41.10 (11.49) | 41.59 (16.40, 61.35) | 40.79 (12.71) |
| Normal Range | Median (Min, Max) | Mean (SD) | Median (Min, Max) | Mean (SD) | |
| Resting temperature (°C) | 35.5–37.03 | 35.8 (32.8, 37.0) | 35.6 (0.9) | 35.6 (33.4, 36.6) | 35.6 (0.7) |
| Resting heart rate (bpm) | 75–85 | 64 (30, 86) | 65.7 (9.6) | 64 (44, 86) | 63.9 (11.3) |
The SF-36v2 scores are based on the norm based scoring system (NBS) which is based on a mean score with a normal range between 47 and 53 NBS points. Resting temperature and resting heart rate data were analysed based on ‘Day 1’ dairy entries
aStrongly influenced by one person with very high TSH
DASS Depression, Anxiety, Stress Score, NET Neuro-Emotional Technique, TSH Serum thyroid stimulating hormone, FT4 Free thyroxine, FT3 Free triiodothyronine, SF-36v2 Short Form-36 Version 2, Min minimum, Max Maximum, SD standard deviation