Table 1.

RT-PCR data for a single dose of a panel of HKMT inhibitor compounds

Entry		Compound	KRT17	FBXO32	JMJD3	EZH2
1	Hit	HKMTI-1-005	4.05	3.65	3.12	0.63
2	Hit	HKMTI-1-022	4.28	29.4	11.56	0.21
3	Hit	HKMTI-1-11	6.95	33.25	6.25	0.22
4	G9ai	BIX01294	1.06	3.34	2.7	0.87
5	G9ai	UNC0638a	1.1	5.5	3.4	0.4
6	EZH2i	GSK343	0.9	1.2	1.0	1.0
7	Negative	HKMTI-1-002	0.66	1.12	1.57	0.86
8	Negative	HKMTI-1-012	1.32	1.06	0.9	1.38
9	Negative	HKMTI-1-013	0.78	0.93	0.87	0.13

RNA levels for target genes are normalised against the housekeeping gene GAPDH, and shown is the fold increase compared to the mock treated sample

^aUNC0638 treatment at 7.5 μM, all other compounds given at 10 μM