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Cell growth IC50 of HKMT inhibitors in MDA-MB-231 cells
| Cell growth assay (IC50 μM) | HKMT-1-005 | BIX-01294 | UNC0638 | GSK343 |
|---|---|---|---|---|
| Cell viability (MTT) | 4.3 | 9.6 | 8.2 | >15 |
| Clonogenic | 0.41 | 1.4 | 1.1 | >50 |
IC50s (μM) for the dual inhibitor compounds HKMT-1-005 and HKMT-1-011 in cell viability (MTT assay) or clonogenic growth assays of MDA-MB-231 cells compared to the starting point for the chemical library BIX-01294, as well as UNC0638 and GSK343
