Fig 2. Time-courses of the plasma concentration, and bone, liver, kidney, and lung accumulation of ¹¹¹In-labeled BSA derivatives in mice after intravenous injection at a dose of 1 mg protein/kg.

The total wet bone weight was estimated as 12% of the body weight, and the radioactivity in the bone was based on activity determined in tibiae and femurs extrapolated to whole wet bone as reported previously [22].Results are expressed as the mean ± S.D. of three mice. ●: BSA, ○: BSA-ALN (3), ▼: BSA-ALN (28), ▽: BSA-ALN (40).