Fig 5. Time-courses of the plasma concentration, and bone, liver, kidney, and lung accumulation of ¹¹¹In-labeled PEG-SOD derivatives in mice after intravenous injection at a dose of 1 mg protein/kg.

The total wet bone weight was estimated as 12% of the body weight, and the radioactivity in the bone was based on activity determined in tibiae and femurs extrapolated to whole wet bone as reported previously [22]. Results are expressed as the mean ± S.D. of three mice. ●: SOD, ○: PEG(10)-SOD, ▼: PEG(10)-SOD-ALN (4).