Fig 7. Effect of SOD derivatives on the growth of metastatic tumor cells in the bones of lower limbs after its administrations 1 and 3 days after tumor injection.
(A) Number of B16BL6/Luc cells in the bones of lower limb of mice administered with PEG-SOD or PEG-SOD-ALN. Mice were sacrificed at 14 days after tumor inoculation. Results are expressed as the mean ± SD of 5–6 mice. *, a statistically significant difference compared with the saline group (P < 0.05). (B) Macroscopic observation of bone metastasis in the mouse lower limb at 14 days after inoculation of B16BL6/Luc cells (2×105 cells/mouse) into the mouse left ventricle. (a) Saline, (b) PEG-SOD, (c) PEG-SOD-ALN.