. 2015 Aug 19;10(8):e0135966. doi: 10.1371/journal.pone.0135966

Table 2. AUC and clearance of ¹¹¹In-labeled ALN-modified proteins in mice after intravenous injection of 1 mg protein/kg.

Compound	AUC(h•% of dose/ml)	CL_total (ml/h)	CL_bone (ml/h)	CL_liver (ml/h)	CL_kidney (ml/h)	CL_lung (ml/h)	CL_urine (ml/h)
GR	545	0.18	0.04	0.02	0.01	0.002	0.003
GR-ALN(4)	130	0.77	0.37	0.22	0.04	0.006	0.02
GR-ALN(17)	1.91	52.4	1.37	35.8	1.87	1.37	0.38
BSA	259	0.39	0.02	0.03	0.01	0.003	0.004
BSA-ALN (3)	265	0.38	0.12	0.03	0.02	0.002	0.03
BSA-ALN (28)	1.86	53.8	2.21	32.6	2.17	3.19	0.41
BSA-ALN (40)	0.81	124	6.73	62.8	2.62	18	2.14
SOD	9.64	10.4	0.1	0.02	8.43	0.02	3.28
SOD-ALN(3)	6.49	15.4	1.51	0.45	11.8	0.02	0.75
SOD-ALN(32)	2.32	43.1	6.26	14.7	7.65	0.36	6.85
PEG(10)-SOD	207	0.48	0.12	0.03	0.02	0.002	0.002
PEG(10)-SOD-ALN(4)	30.8	3.25	0.94	0.11	0.38	0.01	0.06
LZM	4.18	24	1.39	0.65	9.5	0.38	2.99
LZM-ALN(5)	3.48	28.7	2.55	3.06	12.1	0.59	2.43
LZM-ALN(9)	3.5	28.6	2.35	1.76	13.1	0.35	2.54

Table 2. AUC and clearance of 111In-labeled ALN-modified proteins in mice after intravenous injection of 1 mg protein/kg.