TABLE 2.
Absolute MMP and TIMP Concentrations in BAV Aortas
| Median Concentration (pg/ml) | IQR (pg/ml) | Range (pg/ml) | p Value | |
|---|---|---|---|---|
| MMP-1* | ||||
| Elevated WSS | 11.04 | 5.8-20.5 | 2.4-148.2 | 0.027 |
| Normal WSS | 8.84 | 3.5-14.7 | 1.3-19.3 | |
| MMP-2 | ||||
| Elevated WSS | 8093.00 | 5062.0-13691.0 | 293.3-185897.0 | 0.064 |
| Normal WSS | 6060.00 | 2621.0-12910.0 | 197.1-119902.0 | |
| MMP-3 | ||||
| Elevated WSS | 85.28 | 51.6-162.8 | 29.2-485.1 | 0.019 |
| Normal WSS | 58.46 | 43.4-115.9 | 6.8-363.8 | |
| MMP-7* | ||||
| Elevated WSS | 75.3† | 54.2‡ | 8.5-165.6 | 0.653 |
| Normal WSS | 69.3† | 72.7‡ | 0.0-235.3 | |
| MMP-8 | ||||
| Elevated WSS | 2596.0 | 778.4-6258.0 | 22.4-22744.0 | 0.294 |
| Normal WSS | 3594.0 | 1754.0-7706.0 | 404.5-37267.0 | |
| MMP-9 | ||||
| Elevated WSS | 4806.0 | 2377.0-19356.0 | 479.6-74046.0 | 0.596 |
| Normal WSS | 6581.0 | 3582.0-11796.0 | 1588.0-126759.0 | |
| MMP-10* | ||||
| Elevated WSS | 14.2 | 7.2-17.7 | 1.8-45.9 | 0.229 |
| Normal WSS | 10.5 | 8.1-13.1 | 0.7-36.1 | |
| TIMP-1 | ||||
| Elevated WSS | 21442.0 | 11499.0-36679.0 | 4022.0-151540.0 | 0.040 |
| Normal WSS | 14546.0 | 8485.0-19629.0 | 4136.0-149919.0 | |
| TIMP-2 | ||||
| Elevated WSS | 24931.0 | 15476.0-48537.0 | 10399.0-171363.0 | 0.756 |
| Normal WSS | 21721.0 | 14892.0-40513.0 | 6384.0-336986.0 | |
| TIMP-3 | ||||
| Elevated WSS | 4138.0† | 2991.0‡ | 0.0-11961.0 | 0.079 |
| Normal WSS | 3272.0† | 2794.0‡ | 0.0-9862.0 | |
| TIMP-4 | ||||
| Elevated WSS | 92.2 | 47.9-148.0 | 14.7-1173.0 | 0.165 |
| Normal WSS | 79.0 | 57.7-128.9 | 1.9-840.1 |
*
Number of samples outside range of detection: MMP-1 = 7, MMP-7 = 10, MMP-10 = 2.
Concentrations are reported as median [IQR] when non-normally distributed or mean (†) ± SD (‡) when normally distributed. P values denote paired analyses between regions of normal and elevated WSS in each BAV aorta.
IQR = interquartile range (25th quartile - 75th quartile); MMP = matrix metalloproteinase; TIMP = tissue inhibitor of MMP; WSS = wall shear stress; other abbreviations as in Table 1.