Table 3. Clinical Characteristics of Subjects.
| Genetics Dataset | Brain Imaging Dataset | |||||
|---|---|---|---|---|---|---|
| HCs (N = 381) | IBS (N = 278) | HCs (N = 205) | IBS (N = 115) | |||
| Variable | Mean (SD) | Mean (SD) | p-value | Mean (SD) | Mean (SD) | p-value |
| Age (yrs.) | 30.29 (10.68) | 36.4 (12.38) | <0.001 | 30.95 (11.12) | 31.92 (10.2) | 0.178 |
| BMI (SD) | 24.55 (4.7) | 25.17 (5.01) | 0.101 | 24.28 (4.31) | 23.71 (3.99) | 0.346 |
| Female: N (%) | 279 (73.22%) | 209 (75.18%) | 0.59 | 165 (80.49%) | 85 (73.91%) | 0.221 |
| Race | <0.001 | 0.002 | ||||
| Caucasian | 154 (41.4%) | 166 (61.5%) | 82 (40.8%) | 68 (60.2%) | ||
| Asian | 106 (28.4%) | 32 (11.9%) | 66 (32.9%) | 20(17.7%) | ||
| African American | 56 (15.1%) | 37 (13.7%) | 29 (14.4%) | 9 (8.0%) | ||
| Other/Mixed | 56 (15.1%) | 35 (12.9%) | 24 (11.9%) | 16 (14.1%) | ||
| HAD Anxiety (0–21) | 3.35 (2.77) | 7.35 (4.28) | <0.001 | 3.18 (2.7) | 6.49 (3.59) | <0.001 |
| HAD Depression (0–21) | 1.32 (1.75) | 3.83 (3.39) | <0.001 | 1.36 (1.78) | 3.00 (2.98) | <0.001 |
| VSI Score (0–90) | 2.51 (5.07) | 34.75 (16.35) | <0.001 | 2.81 (5.24) | 33.37 (14.76) | <0.001 |
| ETI General Trauma Score (0–11) | 1.51 (1.67) | 2.47 (2.18) | <0.001 | 1.47 (1.52) | 2.06 (1.77) | 0.002 |
| ETI Physical Score (0–5) | 1.14 (1.43) | 1.58 (1.60) | <0.001 | 1.03 (1.34) | 1.33 (1.45) | 0.058 |
| ETI Emotional Score (0–5) | 0.71 (1.33) | 1.58 (1.77) | <0.001 | 0.68 (1.28) | 1.39 (1.68) | <0.001 |
| ETI Sexual Score (0–6) | 0.36 (0.96) | 0.76 (1.53) | <0.001 | 0.37 (0.97) | 0.49 (1.14) | 0.245 |
| IBS Bowel Habit Subtype: N (%) | ||||||
| Constipation | 62 (22.30%) | 31 (26.96%) | ||||
| Diarrhea | 65 (23.38%) | 24 (20.87%) | ||||
| Mixed | 138 (49.64%) | 55 (47.83%) | ||||
| Unspecified | 13 (4.68%) | 5 (4.35%) | ||||
| BSQ Symptoms (SD) | ||||||
| Overall Severity (0–20) | 10.17 (4.56) | 10.67 (4.34) | ||||
| Abdominal Pain (0–20) | 9.34 (5.12) | 9.77 (5.04) | ||||
| Bloating (0–20) | 11.00 (5.36) | 12 (5.15) | ||||
| Usual Severity of IBS (1–5) | 3.13 (0.81) | 3.11 (0.78) | ||||
| Age of Onset of IBS (yrs) | 20.15 (12.04) | 19.39 (9.95) | ||||
| Severity Duration (yrs.) | 11.68 (11.2) | 9.96 (8.5) | ||||
Abbreviations: HCs = healthy controls, IBS = irritable bowel syndrome, BMI = body mass index, HAD = hospital anxiety & depression, ETI = early trauma inventory VSI = visceral sensitivity index Add all of the other clinical traits