Fig. 6.

Motifs enriched in the DMRs. a Enriched sequence motifs identified by the HOMER de novo motif analysis of the cluster-1 and −2 DMRs. The top seven de novo motifs are shown. The fraction containing at least one instance of each motif is given under the P value, with the expected frequency of the motif in random background regions given in parentheses. The closely matched known motifs are shown on the right (top three, similarity score > 0.6). The motif symbols marked with asterisks are sourced from Homo sapiens. b Expression dynamics of messenger RNAs encoding the transcription factors bound to the known motifs in (a). The expression dynamics of the top-ranked transcription factors are shown