Skip to main content
. Author manuscript; available in PMC: 2015 Aug 22.
Published in final edited form as: Integr Biol (Camb). 2015 Jul 6;7(7):815–824. doi: 10.1039/c5ib00105f

Fig. 6.

Fig. 6

Effects of abrogating HGF signals received by hepatocytes on collagen (recipient). (A) Illustration of selective application of c-met receptor inhibitor (SU11274) to one chamber that contained recipient hepatocytes. The other chamber contained hepatocytes on col/HGF (HGF-stimulated). (B-C) PCR results show a ~2 fold decrease in both albumin (B) and HGF (C) expression, suggesting the important role HGF signaling in maintaining hepatocyte functionality. (D) Primary hepatocytes cultured inside microfluidic chambers in presence and absence of SU11274 for 48 h (from 2 to 3 days of culture) were analyzed for albumin expression to ensure that the two groups of recipient hepatocytes were functionally indistinguishable. Results are represented as mean±SD (n=3). *: p-value < 0.05. NS: Non-significant.