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Schematic showing the proposed mechanism involve in the rescue of liver-specific functionality in hepatocytes. (i) Hepatocytes on HGF spots are stimulated to produce more HGF. (ii) These secreted HGF molecules diffuses to neighboring hepatocytes atop collagen spots in close proximity, and (iii) rescue epithelial phenotype by activating autocrine production of HGF. Abbreviation: col/HGF, mixture of collagen type I and HGF.
