Table 3. Overview of the results.
Overview of the results concerning body weight, blood cell count, urea and creatinine blood levels, 99mTc-DTPA and 99mTc-DMSA scintigraphy, and histology. The results are presented as test divided by control (given as percent)
Days after therapy | IA | Body weight (time of death) | White blood cell count | Red blood cell count | Urea | Creatinine | 99mTc-DTPA* | 99mTc-DMSA | Histology |
---|---|---|---|---|---|---|---|---|---|
4 months | 30 MBq | 110% | 50% | 99% | 130% | 100% | 66% (27.5 min) | 140% | Normal |
60 MBq | 98% | ND | ND | 97% | 100% | ND | ND | Normal | |
90 MBq | 110% | 53% | 94% | 91% | 100% | 87% (32.5 min) | 100% | Normal | |
120 MBq | 99% | ND | ND | 92% | 100% | ND | ND | Normal | |
150 MBq | 89% | 63% | 95% | 91% | 100% | 59% (32.5 min) | 120% | Normal | |
8 months | 30 MBq | 90% | ND | ND | 230% | 100% | 62% (32.5 min) | 100% | Normal |
60 MBq | 110% | ND | ND | 140% | 100% | ND | ND | Normal | |
90 MBq | 100% | ND | ND | 140% | 100% | 270% (12.5 min) | 89% | Normal | |
120 MBq | 100% | ND | ND | 280% | 100% | ND | ND | Normal | |
150 MBq | 85% | ND | ND | 280% | 100% | 450% (27.5 min) | 110% | Abnormal | |
12 months | 30 MBq | 98% | ND | ND | 110% | 100% | 160% (17.5 min) | 110% | Normal |
60 MBq | 120% | ND | ND | 82% | 100% | ND | ND | Normal | |
90 MBq | 110% | ND | ND | 140% | 100% | 910% (27.5 min) | ND | Normal | |
120 MBq | 110% | ND | ND | 160% | 100% | ND | ND | Normal | |
150 MBq | 110% | ND | ND | 520% | 110% | ND | 100% | Abnormal |
*Values in parenthesis indicates time after 99mTc-DTPA injection where highest deviation from control was observed
ND = not done