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. 2015 Aug 21;3:51. doi: 10.1186/s40478-015-0230-2

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© Umeda et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Impaired axonal transport and aberrant dendritic distribution of mitochondria in APP_OSK-expressing neurons. Rat primary neurons were triply transfected with APP, Mt-eYFP, and BFP. a Transport of mitochondria in living neurons was recorded for 300 s, and those in 100-μm segments of the axon were analyzed. b Compared with mock-transfectants, bidirectional transport of mitochondria in axons was reduced in APP_OSK-, but not APP_WT-, expressing cells. c In dendrites, mitochondria were evenly distributed along the dendritic shafts in mock-transfectants (a-c) and APP_WT-expressing cells (d-f). In contrast, mitochondria in dendrites of APP_OSK-expressing cells (g-i) were of shorter length and unevenly distributed. Scale bar, 20 μm