Fig 1. Dopamine receptors are enriched in striatal raft fractions but not affected by methamphetamine treatment.

Membranes were prepared from rat striatal homogenates and separated by density gradient centrifugation. Results shown are representative of or the average of at least 3 independent experiments except where indicated. Raft fractions 4–7 were enriched in cholesterol (A), in flotillin but not transferrin receptor (TfR) or calnexin immunoreactivity (B), and in dopamine D2 (C) and D1 receptor binding activity (D; n = 2). Dopamine receptor distribution was not altered by acute or repeated treatment with methamphetamine.