Table 1. Proteins whose abundance in striatal raft fractions was altered by treatment with methamphetamine.
| Proteins Altered by Acute Methamphetamine | ||
|---|---|---|
| Protein Description | log2 (METH/Saline) | |
| heat shock 70 kDa protein 4 | 1.47 | |
| potassium voltage-gated channel KCNA4 | 1.32 | |
| myosin-Va | 1.20 | |
| myosin-9 | 1.19 | |
| serotransferrin precursor | 1.03 | |
| Eph receptor A4 | 1.01 | |
| myosin-10 | 0.91 | |
| ser/thr-protein phosphatase 2A, PPP2R1A | 0.77 | |
| PREDICTED: ankyrin 2, neuronal | 0.76 | |
| striatin | 0.72 | |
| microtubule-associated protein 1A | 0.68 | |
| adaptor-related protein complex 2, alpha 1 | 0.55 | |
| clathrin heavy chain 1 | 0.45 | |
| NAD-dependent deacetylase sirtuin-2 | -0.44 | |
| neuronal growth regulator 1 precursor | -0.50 | |
| rho-related GTP-binding protein RhoG | -0.64 | |
| opalin | -0.78 | |
| cytochrome c oxidase subunit 6B1 | -0.83 | |
| ras-related protein 1A,1B group | -0.84 | |
| probable saccharopine dehydrogenase | -1.01 | |
| ras-related protein Rab10 | -1.06 | |
| ras-related protein R-Ras2 | -1.19 | |
| glycerol-3-phosphate dehydrogenase [NAD+] | -1.95 | |
The raft localization of 23 proteins was significantly altered by acute treatment with methamphetamine as determined by spectral counts in raft fractions from methamphetamine-treated rats verses saline-treated rats (METH/Saline). Significance thresholds were set at p < 0.05 and average spectral counts >3. Two independent experiments (n = 2 each) were combined for a total of n = 4 (4 pooled samples from 8 rats).