Table 1.
GO and KEGG pathway enrichment anal ysis of DEGs in lung SCC
| Gene expression | Category | Term | Count | P value |
|---|---|---|---|---|
| Up-regulated | GOTERM_BP_FAT | GO:0006955, immune response | 58 | 3.95E−33 |
| GOTERM_BP_FAT | GO:0006952, defense response | 42 | 5.74E−20 | |
| GOTERM_BP_FAT | GO:0009611, response to wounding | 36 | 6.34E−17 | |
| GOTERM_BP_FAT | GO:0006954, inflammatory response | 28 | 1.41E−15 | |
| GOTERM_BP_FAT | GO:0019882, antigen processing and presentation | 13 | 2.68E−10 | |
| GOTERM_CC_FAT | GO:0005576, extracellular region | 70 | 8.37E−15 | |
| GOTERM_CC_FAT | GO:0044421, extracellular region part | 44 | 1.06E−12 | |
| GOTERM_CC_FAT | GO:0005615, extracellular space | 34 | 1.17E−10 | |
| GOTERM_CC_FAT | GO:0042611, MHC protein complex | 11 | 3.75E−09 | |
| GOTERM_CC_FAT | GO:0042613, MHC class II protein complex | 7 | 2.00E−06 | |
| GOTERM_MF_FAT | GO:0008009, chemokine activity | 10 | 2.21E−09 | |
| GOTERM_MF_FAT | GO:0042379, chemokine receptor binding | 10 | 3.99E−09 | |
| GOTERM_MF_FAT | GO:0005125, cytokine activity | 16 | 7.17E−09 | |
| GOTERM_MF_FAT | GO:0032395, MHC class II receptor activity | 6 | 1.97E−06 | |
| GOTERM_MF_FAT | GO:0019865, immunoglobulin binding | 4 | 6.21E−04 | |
| KEGG_PATHWAY | hsa05330: allograft rejection | 12 | 1.53E−11 | |
| KEGG_PATHWAY | hsa05332: graft-versus-host disease | 12 | 4.09E−11 | |
| KEGG_PATHWAY | hsa04940: type I diabetes mellitus | 12 | 1.00E−10 | |
| KEGG_PATHWAY | hsa05320: autoimmune thyroid disease | 12 | 9.74E−10 | |
| KEGG_PATHWAY | hsa04514: cell adhesion molecules (CAMs) | 17 | 1.01E−09 | |
| Down-regulated | GOTERM_BP_FAT | GO:0055088, lipid homeostasis | 10 | 1.22E−08 |
| GOTERM_BP_FAT | GO:0042632, cholesterol homeostasis | 9 | 1.87E−08 | |
| GOTERM_BP_FAT | GO:0055092, sterol homeostasis | 9 | 1.87E−08 | |
| GOTERM_BP_FAT | GO:0065005, protein-lipid complex assembly | 6 | 2.18E−07 | |
| GOTERM_BP_FAT | GO:0034377, plasma lipoprotein particle assembly | 6 | 2.18E−07 | |
| GOTERM_CC_FAT | GO:0005615, extracellular space | 35 | 4.43E−12 | |
| GOTERM_CC_FAT | GO:0044421, extracellular region part | 39 | 1.70E−10 | |
| GOTERM_CC_FAT | GO:0005576, extracellular region | 52 | 3.66E−07 | |
| GOTERM_CC_FAT | GO:0034385, triglyceride-rich lipoprotein particle | 6 | 4.09E−06 | |
| GOTERM_CC_FAT | GO:0034361, very-low-density lipoprotein particle | 6 | 4.09E−06 | |
| GOTERM_MF_FAT | GO:0008289, lipid binding | 19 | 6.35E−06 | |
| GOTERM_MF_FAT | GO:0004866, endopeptidase inhibitor activity | 11 | 8.62E−06 | |
| GOTERM_MF_FAT | GO:0005496, steroid binding | 8 | 1.02E−05 | |
| GOTERM_MF_FAT | GO:0004867, serine-type endopeptidase inhibitor activity | 9 | 1.31E−05 | |
| GOTERM_MF_FAT | GO:0030414, peptidase inhibitor activity | 11 | 1.38E−05 | |
| KEGG_PATHWAY | hsa04610: complement and coagulation cascades | 7 | 3.32E−04 | |
| KEGG_PATHWAY | hsa00830: retinol metabolism | 6 | 8.02E−04 | |
| KEGG_PATHWAY | hsa00860: porphyrin and chlorophyll metabolism | 5 | 9.97E−04 | |
| KEGG_PATHWAY | hsa00053: ascorbate and aldarate metabolism | 4 | 0.0015 | |
| KEGG_PATHWAY | hsa00040: pentose and glucuronate interconversions | 4 | 0.0018 |
GO gene ontology, KEGG kyoto encyclopedia of genes and genomes, DEGs differentially expressed genes, SCC squamous-cell carcinoma, BP biological process, CC cellular component, MF molecular function