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. 2015 Aug 20;10(8):e0136178. doi: 10.1371/journal.pone.0136178

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© 2015 Kaltofen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — Na⁺ enters the apical membrane of alveolar epithelial cells through ENaC and is actively extruded by the Na,K-ATPase in the basolateral membrane compartment, whereas K⁺ ions are recycled by K⁺ channels. Thereby pulmonary fluid is absorbed as it passively follows the osmotic gradient generated by vectorial Na⁺ transport.