Table 1. Eight Metabolic Hormone Levels in Studied Subjects According to H. pylori Eradication Status.
| Hormone | Median (95% CI*) hormone concentration (pg/ml) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (N = 29) | 6 months post-eradication (N = 29) | 12 months post-eradication (N = 18) | Comparison of hormone concentration at baseline and 6 months post-eradication (p-value) a | Comparison of hormone concentration at baseline and 12 months post-eradication (p-value) a | |||||||||
| Pre-prandial | Post-prandial | p-value b | Pre-prandial | Post-prandial | p-value b | Pre-prandial | Post-prandial | p-value b | Pre-prandial | Post-prandial | Pre-prandial | Post-prandial | |
| Active Amylin | 7.3 | 44.3 | 0.013 | 18.5 | 46.1 | 0.006 | 37.8 | 98.6 | 0.008 | 0.24 | 0.48 | 0.036 | 0.017 |
| (0–31.1) | (34.2–52) | (0–24.9) | (31.1–53.6) | (0–84.1) | (54.8–136.4) | ||||||||
| Acyl-ghrelin | 12.7 | 10.2 | 0.022 | 11.8 | 12 | 0.45 | 15.4 | 7.6 | 0.022 | 0.26 | 0.29 | 0.17 | 0.72 |
| (6.5–19.4) | (7.1–16.4) | (7.1–17.1) | (6.5–16.5) | (8.8–27.1) | (6.5–19.6) | ||||||||
| Total GIP | 25.4 | 281.3 | 0.005 | 35.1 | 222.2 | 0.002 | 41.1 | 276 | 0.005 | 0.88 | 0.64 | 0.09 | 0.022 |
| (15.4–52.5) | (190.8–302.5) | (20.7–48.5) | (200.8–317.8) | (25.1–70.7) | (237–430.4) | ||||||||
| GLP-1 | 17.4 | 44.4 | 0.013 | 17.4 | 49.6 | 0.002 | 22.5 | 63.5 | 0.005 | 0.21 | 0.041 | 0.68 | 0.005 |
| (13.6–32.1) | (25.6–55.5) | (0–29.1) | (37–59.6) | (0–47.5) | (47.2–84.2) | ||||||||
| Insulin | 293.3 | 2235.4 | 0.003 | 292.1 | 1937.9 | 0.002 | 504 | 3455.3 | 0.005 | 0.88 | 0.16 | 0.14 | 0.09 |
| (209.5–392.2) | (1842.5–3198.5) | (251.4–445.3) | (1518.5–2436.6) | (310–559.4) | (2252.8–4449.2) | ||||||||
| Leptin | 11091.8 | 9510.6 | 0.016 | 10917.7 | 9805 | 0.012 | 6059.6 | 7947 | 0.17 | 0.42 | 0.16 | 0.86 | 0.44 |
| (7318.1–13249.7) | (6427.7–10939.4) | (5477.9–13279.9) | (5124.9–13090.1) | (3000.1–16842.4) | (5216.5–14507.5) | ||||||||
| PP | 16.1 | 75.5 | 0.004 | 16.4 | 88.3 | 0.002 | 33 | 136.7 | 0.005 | 0.65 | 0.29 | 0.028 | 0.009 |
| (0–39.5) | (52.4–100.2) | (0–34) | (55.8–157.8) | (5.6–62.9) | (77.9–229.2) | ||||||||
| Total PYY | 30.7 | 65.9 | 0.05 | 35.6 | 86.5 | 0.002 | 96.3 | 174.4 | 0.007 | 1 | 0.006 | 0.021 | 0.005 |
| (0–44.6) | (0–83.1) | (0–53.4) | (77.2–95.7) | (0–150.2) | (140.9–219.5) | ||||||||
p-values< 0.05 were indicated in bold.
*Bootstrapped 95% confidence interval (CI) was based on 1000 replicates.
aWilcoxon’s signed rank test was used in comparing baseline and post-H. pylori eradication.
bWilcoxon’s signed rank test was used in comparing pre-prandial and post-prandial values.