Table 1.

Examples of interactions between modular domains and linear motifs

Protein	Domain	Consensus motif	Target protein/binding peptide	Function	Reference
GRB2	SH2	pY-x-(E/N)	ERBB3/pYMN	Ras signaling	[93]
GRB2	SH3	P-x-x-P-x-(R/K)	SOS1/PPVPPR	Ras signaling	[94]
SUMO1	SUMO	(V/I/L)-(V/I/L)-(D/E)-(V/I/L)	PIAS1/VIDL	Sumoylation	[66]
SDCBP	PDZ	Φ-x-Φ-coo-	SDC1/EFYA-coo-	Trafficking	[95]
YAP1	WW	PP-x-Y	TP73/PPPY	Transcriptional regulation	[96]

“Φ” indicates a hydrophic residue and “x” any amino acid