Table 5. Phenotipic frequencies for cytochrome P450 (CYP) 2C9, 2C19 and 3A5 in healthy controls, cases and tolerants (EM = normal metabolizers, IM and PM = decrease function, UM and UMH = increase function) as predicted by SNP genotype.
| Gene (SNP) | Enzymatic Phenotype Group | Phenotypic Frequency (%) | P Value | ||
|---|---|---|---|---|---|
| Healthy controls (%) | Cases (%) | Tolerants (%) | |||
| CYP2C9 (rs1057910, rs1799853) | EM | 251 (71.1) | 43 (81.1) | 54 (65.9) | |
| IM | 97 (27.5) | 8 (15.1) | 25 (30.5) | 0.083 | |
| PM | 5 (1.4) | 2 (3.8) | 3 (3.7) | ||
| CYP2C19 (rs4244285, rs4986893, rs12248560, rs11188072) | EM | 163 (48.4) | 24 (47.1) | 41 (51.3) | |
| IM/PM | 79 (23.4) | 12 (23.5) | 20 (25) | 0.945 | |
| UM/UMH | 95 (28.2) | 15 (29.4) | 19 (23.8) | ||
| CYP3A5 (rs776746) | EM | 37 (10.6) | 8 (14.8) | 38 (46.3) | |
| IM | 122 (34.9) | 23 (42.6) | 19 (23.2) | 0.0005 OR = 4.9 | |
| PM | 191 (54.6) | 23 (42.6) | 25 (30.5) | ||