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. 2015 Aug 22;34(1):86. doi: 10.1186/s13046-015-0198-6

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© Fang et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Plasma levels of miR-24, miR-320a, miR-423-5p are better biomarkers for early detection of CRC than currently used CEA, CA19-9. a-f Two-parameter classification is used to detect early stages of CRC. The cut-off value 5.0 ng/mL for CEA is, and 27U/ mL for CA19-9. The data is presented as log₂. The cut-off values for miR-24, miR-320a and miR-423-5p are −1.731, −1.006, and −0.854, respectively. The data is calculated from the ROC curve. (g), Detection rates of the three microRNAs CEA, and CA19-9 in a total of 54 patients with early stages of CRC