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. 2015 Aug 20;11(8):e1005115. doi: 10.1371/journal.ppat.1005115

Fig 7. Schematic of R. typhi entry.

Fig 7

R. typhi entry has been broken down into five conceptual stages: binding (1); extension of pseudopodia (2); membrane fusion and internalization (3); formation of early endosome (4); bacterial escape from endosome (5). Schematic is a representation of micrographs from Figs 5B, 5C and 6C. Inset depicts hypothetical recruitment and activation of PIP5K via RalFRt-activated Arf6, which results in PI(4,5)P2 enrichment and actin rearrangement to facilitate for R. typhi entry.