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. 2015 Aug 20;11(8):e1005446. doi: 10.1371/journal.pgen.1005446

Fig 10. MOM-5/Frizzled through small GTPases functions to negatively regulate the UNC-5 receptor for UNC-6/Netrin.

Fig 10

Here, we provide a target for the non-canonical Wnt signaling pathway mediated by the MOM-5/Frizzled receptor, CED-12/ELMO, and CED-10/Rac [5], placing MOM-5 and small GTPases upstream of UNC-5 to negatively regulate unc-5 and determine the polarity of phase 3 DTC migration. MIG-2/RhoG had been shown to function as an activator of CED-12/ELMO by recruiting the ELMO/DOCK180 complex to the plasma membrane during engulfment of apoptotic cells [11]. It is possible that also in the DTCs MIG-2/RhoG functions upstream of CED-12/ELMO to regulate CED-10/Rac. Ligand in red, small GTPase signaling molecules in orange, and receptors in Green.