Table 4. Numbers of significantly regulated genomic loci, by CC-486 dosing schedule.^* .

	Cycle 1—Day 15		Cycle 1—Day 22		Cycle 1 End (Day 28±1)
Cycle 1	Up	Down	Up	Down	Up	Down
CC-486 300 mg QD x 14 days (n = 18)	0	88	0	434	0	133
CC-486 300 mg QD x 21 days (n = 17)	0	1470	0	2807	0	1483
CC-486 200 mg BID x 21 days (n = 5)	1	5089	0	5586	2	4447

* No loci were significant at the 0.05 level for the CC-486 200 mg BID x14 days dosing regimen, mainly due to small sample size (n = 3).

BID = twice daily; QD = once daily