Table 5. Results of the full factorial analysis for the contrast alcohol versus neutral and post hoc brain imaging results of the single placebo-controlled HF-rTMS session.

Cluster size		Anatomical region	hemisphere	BA	Peak	Peak	Peak
					F-value	Z-value	coordinates
Main effect of TIME (before and after HF-rTMS): F-contrast alcohol versus neutral
Block:
No Significant clusters emerged
Event:
110		Lateral ventricle	Right	-	16.72	3.58	4–16 20
160		Putamen	Right	-	13.94	3.28	24 16–8
86		Inferior Frontal Gyrus	Left	47	11.60	2.99	-28 28–4
Main effect of STIMULATION (active versus sham HF-rTMS): F-contrast alcohol versus neutral
Block:
No Significant clusters emerged
Event:
No significant clusters emerged
Interaction between TIME (before and after HF-rTMS) and STIMULATION (active versus sham):
F-contrast alcohol versus neutral
Block:
No Significant clusters emerged
Event:
131		Insula	Right	-	14.48	3.34	40 4 4
100		Inferior Frontal Gyrus	Right	9	13.46	3.22	48–2 24
Post hoc paired t-tests	Cluster size	Anatomical region	hemisphere	BA	Peak	Peak	Peak
only performed for the EVENT paradigm					F-value	Z-value	coordinates
Active HF-rTMS		No significant clusters
Pre>Post		emerged
Post>Pre	49	Insula	Right	-	3.83	3.55	38–2 8
	68	Precentral Gyrus	Right	6	3.31	3.12	50–2 26
Sham HF-rTMS
Pre>Post	18	Insula	Right	13	3.31	3.12	38 14–2
Post>Pre		No significant clusters
		emerged

For the interaction effects, we listed those clusters that reached significance with a P<0.005 AlphaSim corrected voxel threshold. For each cluster we reported the F-value, Z-value and MNI coordinates at the position of the maximum, the cluster size and the appropriate Brodmann Area (BA). For each significant cluster of the post hoc results, we reported the T-value, Z-value and MNI coordinates at the position of the maximum, the cluster size and the appropriate BA.