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. 2015 Mar 29;6(16):14153–14164. doi: 10.18632/oncotarget.3686

Figure 4. Up-regulated or down-regulated miR-221/222 levels in pancreatic cancer cell lines decrease or increase the rate of apoptosis.

Figure 4

(A and B) Cell apoptosis was analyzed by FCM in Panc-1 or SW-1990 cells at 48 h after transfection of miR-221/222 mimics, inhibitors or negative controls. The data showed that a significantly lower apoptotic rate was found in the miR-221/222 mimic-transfected Panc-1 cells compared with their controls (0.97 ± 0.32%/0.88 ± 0.26%). A similar phenomenon was observed in the SW-1990 cells (0.84 ± 0.31%/0.57 ± 0.14%). The apoptotic rates of the miR-221/222 inhibitor-transfected cells were 7.55 ± 1.23%/7.97 ± 1.81% in Panc-1 cells and 6.31 ± 1.36%/6.88 ± 1.16% in SW-1990 cells. (C and D) Ratio of apoptosis in cells transfected with oligoribonucleotides (*p < 0.05). The data are expressed as the mean ± SD of three independent experiments.