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. 2015 May 4;6(16):14497–14506. doi: 10.18632/oncotarget.3988

Figure 1. NSL complex binds to c-Jun target genes upon c-Jun activation.

Figure 1

A. Diagram of the c-Jun gene locus and Cyclin D1 gene locus, which are both c-Jun target genes. Arrows indicate the primers used in ChIP assay. B. H4K16 acetylation levels at c-Jun target genes are dramatically increased upon c-Jun activation. HEK-293 cells were treated with Anisomycin for 30 minutes to activate c-Jun. The cells were then subjected to ChIP analysis using the indicated antibodies. Untreated cells were used as a control. The data are presented as mean ± standard deviation of 3 independent experiments. *P < 0.001. C., D. NSL complex binds to c-Jun target genes upon c-Jun activation. HEK-293 cells were treated with Anisomycin for 30 minutes to activate c-Jun. The cells were then subjected to ChIP analysis using the indicated antibodies. Untreated cells were used as a control. The data are presented as mean ± standard deviation of 3 independent experiments. *P < 0.001.