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. 2015 May 4;6(16):14497–14506. doi: 10.18632/oncotarget.3988

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Copyright: © 2015 Liu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A., B. Depletion of the NSL complex subunits significantly reduces the expression of c-Jun target genes. HEK-293 cells were treated with siRNAs specific to MOF, NSL-specific subunits or MSL-specific subunits followed by treatment with Anisomycin. The expression levels of c-Jun and Cyclin D1 were measured by qPCR. The cells treated with only Anisomycin were used as a control. The data are presented as mean ± standard deviation of 3 independent experiments. *P < 0.01. C. Depletion of the NSL complex subunits significantly reduces the H4K16 acetylation levels at c-Jun target genes. HEK-293 cells were treated with siRNAs specific to MOF, NSL-specific subunits or MSL-specific subunits followed by treatment with Anisomycin. The resultant cells were then subjected to ChIP analysis using the indicated antibodies. The cells treated with only Anisomycin were used as a control. The data are presented as mean ± standard deviation of 3 independent experiments. *P < 0.01.