Figure 4. Comparison of efficacy of S. typhimurium A1-R or VNP20009 on the Lewis lung cancer.

When the average tumor volume reached approximately 70 mm³, S. typhimurium A1-R (1×10⁷ CFU) or VNP-20009 (1×10⁷ CFU) were injected into the tail vein once a week. Primary tumor sizes were measured with a caliper. A: Tumor growth curve. B: Tumor weight in S. typhimurium A1-R- and VNP20009-treated mice, as compared to control mice (*p<0.05; **p<0.01) at day 10 after treatment. n = 5 mice for each group