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. Author manuscript; available in PMC: 2016 Aug 20.
Published in final edited form as: Chem Biol. 2015 Aug 6;22(8):1122–1133. doi: 10.1016/j.chembiol.2015.07.008

Fig. 2. Scatter density plot for the 18 MMPs.

Fig. 2

Density plots of Z-score versus raw sequencing counts of 18,583 peptide substrates. X-axis and Y-axis denote the Z-score of substrate cleavage and log2 raw DNA counts in an MMP digest sample, respectively. Darker blue represents a higher density of substrates, with outlying substrates shown as dots (the Z-score >2.5; p-value <0.0062 by one tail test). All of the MMPs, except MMP-7 and MMP-19, exhibited >500 substrates with the Z-score >2.5. Because of a limited number of the efficiently cleaved peptide substrates, MMP-7 and MMP-19 were not analyzed further.