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. Author manuscript; available in PMC: 2016 Aug 21.
Published in final edited form as: ACS Chem Biol. 2015 May 22;10(8):1887–1896. doi: 10.1021/acschembio.5b00101

Figure 3.

Figure 3

Evolution of HCV resistant to telaprevir and HPI. (A) Sensitivity of the HCVsg 1b(con1)-Rluc replicon to telaprevir after incubation with DMSO (circles) or telaprevir (squares) for 3 weeks. (B) Sensitivity of the HCVsg 1b(con1)-Rluc replicon to HPI after incubation with DMSO (circles) or HPI for 3 weeks (trangles) or 6 weeks (squares). After 3 or 6 weeks of selection, the susceptibility of evolved cells lines to each compound was determined by measuring Renilla luciferase activity remaining after exposure to various amounts of each telaprevir or HPI for 3 days.