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. Author manuscript; available in PMC: 2016 Aug 21.
Published in final edited form as: ACS Chem Biol. 2015 May 22;10(8):1887–1896. doi: 10.1021/acschembio.5b00101

Figure 4.

Figure 4

Sensitivity of HCVsg 1b(con1)-Rluc replicons carrying telaprevir-resistance mutations. (A) Normalized Renilla luciferase remaining after exposure of HCVsg 1b(con1) (circles), HCVsg 1b(con1) carrying the NS3 R155K substitution (squares), or HCVsg 1b(con1) carrying both a R155K and V36A substitutions (triangles) to various amounts of telaprevir for 3 days. (B) Normalized Renilla luciferase remaining after exposure of HCVsg 1b(con1) (circles), HCVsg 1b(con1) carrying the NS3 R155K substitution (squares), or HCVsg 1b(con1) carrying both a R155K and V36A substitutions (triangles) to various amounts of HPI for 3 days.