Table 1. Meta-analysis of 3q29 deletion and schizophrenia.
Ref. | Ethnicity | Selection of controls | SZ cases | Case 3q29 del | Controls | Control 3q29 del | CMH OR (95% CI, P-value) with this sample removed |
---|---|---|---|---|---|---|---|
Levinson et al.3 | European American | EM | 2667 | 4 | 2648 | 0 | 36.4 (4.7 –1799.3, 8.4e−07) |
Levinson et al.3 | African American | EM | 1273 | 1 | 963 | 0 | 40.2 (5.4–1924.3, 1.0e−07) |
Szatkiewicz et al.4 | Swedish | EM | 4129 | 5 | 5478 | 0 | 33.4 (4.2–1695.3, 3.4e−06) |
Rees et al.6 | Mixed (95% European ancestry) | EM | 6882 | 4 | 11 255 | 0 | 33.3 (4.2–1691.5, 2.6e−06) |
Mulle et al.9 | Ashkenazi Jewish | EM | 554 | 1 | 1014 | 0 | 39.0 (5.2–1882.6, 1.6e−07) |
Walsh et al.10 | Mixed (78% Caucasian) | EM | 150 | 1 | 256 | 0 | 39.1 (5.3–1887.4, 1.5e−07) |
Rudd et al.11 | No information (recruited from Iowa) | No information (recruited from Iowa) | 166 | 0 | 52 | 0 | 41.1 (5.6–1953.6, 5.8e−08) |
Derks et al.12 | Scottish (ID with SZ) | Scottish (ID w/o SZ) | 64 | 0 | 66 | 0 | 41.1 (5.6–1953.6, 5.8e−08) |
Ahn et al.13 | COS: ‘highly heterogeneous' | Unaffected sibs of cases | 126 | 0 | 69 | 0 | 41.1 (5.6–1953.6, 5.8e−08) |
Priebe et al.14 | German | EM | 1637 | 0 | 1627 | 0 | 41.1 (5.6–1953.6, 5.8e−08) |
Van Den Bossche et al.15 | Belgian, Swedish, Scottish | EM | 1259 | 2 | 1173 | 0 | 38.9 (5.2–1881.2, 2.1e−07) |
Buizer-Voskamp et al.16 | Dutch | EM | 834 | 1 | 672 | 0 | 40.1 (5.4–1922.3, 1.0e−07) |
Stefansson et al.17 | Northern European/European | EM | 1438 | 0 | 33,246 | 1 | ∞ (6.7–∞, 2.7e−08) |
Magri et al.18 | Italian | EM | 172 | 1 | 160 | 0 | 40.0 (5.4–1917.5, 1.1e−07) |
Xu et al.19 | Afrikaner SZ trios (de novo CNV) | Afrikaner control trios (de novo CNV) | 152 | 0 | 156 | 0 | 41.1 (5.6–1953.6, 5.8e−08) |
International Schizophrenia Consortium20 | Mixed European | EM | 3391 | 2 | 3181 | 0 | 38.9 (5.2–1880.7, 2.1e−07) |
Costain et al.21 | European ancestry | EM | 420 | 0 | 416 | 0 | 41.1 (5.6–1953.6, 5.8e−08) |
Total | 25 314 | 22 | 62 432 | 1 | |||
Raw OR | 54.3 (95% CI: 8.8–2215.7, P-value 2.2e−11) | ||||||
CMH OR | 41.1 (95% CI: 5.6–1953.6, P-value 5.8e−08) |
Abbreviations: CI, confidence interval; CNV, copy number variation; CMH, Cochran–Mantel–Haenszel; COS, childhood-onset schizophrenia; EM, ethnically matched; ID, intellectual disability; OR, odds ratio; SZ, schizophrenia.